Virus Rhinitis and Primary Ciliary Dyskinesia

The symptoms of these two disorders are the same, but it is almost certain that in Irish wolfhounds there are two separate disorders.

The symptoms are rhinitis (nasal discharge, usually greenish in colour and thick), a cough, wheezing breathing (the common name of virus rhinitis is snuffles). The lungs fill up with fluid and there are episodes of pneumonia. On antibiotics the lungs clear but it comes back when off them.

Some puppies are born with a nasal discharge. These are usually severely affected and survive only a few weeks. Others do not develop symptoms until later, sometimes months or even years later. The continual bouts of pneumonia cause damage to the lungs similar to - but not as severe as - that caused by cystic fibrosis. There is marked variation in the worst and least affected animals.

In the 1960s a breeder who had a problem with several litters instigated veterinary research into the disorder. It was decided that the condition was due to a viral infection (although the virus has not been isolated) but that there was an immune component, because it could not be given to healthy puppies even by injecting material from affected puppies. It was thus decided that a puppy was born with an immune deficiency and picked up the causative virus from its mother during birth. In the 1970s another researcher was looking into the condition in various breeds of dog, using the same basis for research, that of it being a viral infection of animals which were immune compromised.

It needs to be borne in mind that this is not a virus infection per se; it is an immunodeficiency disorder and the deficiency in the immune system allows the virus (if that is what the organism is) to take over and produce the symptoms that are recognised as virus rhinitis. This is different from an acute infection such as distemper but very similar in its cause to demodectic mange, in which the mite is present in all dogs but only causes a problem when there is immunodeficiency. (see page on the immune system for more details)

Primary ciliary dyskinesia (PCD) is quite a recent discovery and occurs in humans, dogs, cats, pigs, rats and mice. It is a genetic factor (usually autosomal recessive, occasionally autosomal dominant) and is due to the cilia (the hairlike structures on the mucus membranes lining areas such as the nose and lungs) being deformed structurally and in the way they are anchored. The cilia move together in a wave-like fashion to move fluids through the system and protect the respiratory system from inhaled pathogens. In PCD they are incorrectly formed, cannot move in unison, and so fluids collect, as do pathogens.

In diagnosis, apart from finding deformed cilia, the heart in about fifty per cent of cases is seen on x-ray (dorsal-ventral or ventral-dorsal, not lateral) to be over to the right instead of the left. In some cases the other internal organs may also be transposed. In males the sperm are affected, because the tail of the sperm is formed from cilia. This means that affected males are sub- or infertile, with a large proportion of the sperm immotile. The reproductive organs in bitches are likely to be very immature.

In a few cases in both humans and dogs, the cilia are structurally normal but their function is abnormal. This means that the cilia either do not move together in the normal wave motion that carries fluids through the respiratory system, or the beat frequency is abnormal.

There may be evidence on x-ray of bronchitis, bronchiectasis, and bronchopneumonia. Cases of PCD have been misdiagnosed as instances of canine distemper viral infection because of the characteristic symptoms of purulent nasal discharge, bronchiectiasis and bronchopneumonia.

Other organs can also be affected by PCD. These include the ears (giving rise to otitis media), kidneys (renal fibrosis), the brain (hydrocephalus), and the bones (abnormal sternum, vertebrae, and ribs).

Microorganisms that have been isolated from animals with PCD include Streptococcus, Staphylococcus, Pseudomonas and Mycoplasma species.

PCD has been diagnosed in Irish wolfhounds in Australia, the USA, and some European countries. One wolfhound in England, apparently suffering from virus rhinitis, has been tested and does not have PCD, so presumably he does have virus rhinitis. As others are tested we will gain some idea of whether we do have PCD in this country. The problem is (as was found in the '60s research) the condition is not widespread so it can be difficult finding enough animals to test. It has always appeared, then disappeared for a few years, then returned. All wolfhounds go back to just two littersisters, and there was only one stud dog used during the Second World War in Britain, so what appears elsewhere is likely to also be in this country.

One wolfhound in England appeared healthy until two years of age, then developed the symptoms of virus rhinitis after being in contact with a hound that had a nasal discharge but was not unwell. It was presumed at the time that he was susceptible to but had not previously come in contact with the causative organism. However, there have been at least two Newfoundlands which have not been diagnosed as having PCD until the age of 5 and 9, although that may not have been because they had no symptoms until those ages.

The usual treatment given to dogs with PCD or virus rhinitis is antibiotics, and some dogs are on antibiotics constantly otherwise they develop pneumonia. One Newfoundland breeder who had PCD occur in two consecutive litters has suggested that this treatment is not beneficial to the dog and that a product called ChestEze, made by Sieger, works well and is less damaging than antibiotics. It comes in tablet form and is available over the counter in pharmacies.

One owner of a wolfhound with virus rhinitis got excellent results by giving colloidal silver, which is available from health food shops and comes in a liquid. Dosage would be twenty drops three times daily until symptoms disappeared and then continue treatment at a lower rate such as twenty drops once a day. The dosage can be increased if symptoms return. Colloidal silver is safe to give undiluted but can be given with food. It can also be used externally if required. As with antibiotics, follow up a period of treatment with probiotics such as Lactobacillus acidophilous capsules to replace the beneficial gut flora.

Aerobic Oxygen can be helpful in respiratory disorders. Dosage is the same as for Colloidal Silver (twenty drops three times daily) but the drops should be given in liquid, although this can then be added to food.

The aromatherapy oil mix called RAVEN is a combination of ravensara and eucalyptus radiata, which gives strength in fighting respiratory disease, infections and may help alleviate symptoms of rhinitis and pneumonia. Can be diffused in an aromatherapy burner, and applied topically over lungs and throat.   The Irish Wolfhound Foundation page on Rhinitis/Primary Ciliary Dyskinesia  The U.K. Newfoundland Club page on Primary Ciliary Dyskinesia

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Liver Shunt

The medical term for this condition is Portosystemic shunt. The portal vein is the one that carries blood to the liver. Portosystemic shunts (PSS) are abnormal vessels that directly communicate between the portal vein and vessels in the systemic circulation, bypassing the liver either completely or partially. Shunts may be within the liver (intrahepatic shunts) or outside the liver (extrahepatic shunts).

Normally, circulation leaving the stomach, intestines, spleen, and pancreas enters the portal vein and flows through the liver before returning to the systemic circulation. Blood leaving the gastrointestinal tract contains nutrients, hormones, toxins, and bacteria, which normally are removed by the liver. When some of these substances escape into the systemic circulation, as in the case of portosystemic shunts, clinical signs of hepatic (liver) disease appear. Besides the problems of substances that should have been removed by the liver getting into the bloodstream, the liver does not receive the blood supply and nutrients it requires. This leads to atrophy of the liver, and nervous symptoms as well as other possible signs of hepatic insufficiency.

The condition that exists in Irish wolfhounds is persistent ductus venosus. The ductus venosus is a foetal vessel (it exists in the foetus to bypass the liver and take blood from the gastrointestinal tract into the umbilical vein) but it should close within sixty hours after birth, so that the entire portal blood flow perfuses the liver.

Clinical signs are highly variable. Puppies may not thrive and will have obvious problems such as stunted growth and failure to gain weight at a very early age, or they may appear completely normal, grow on well and seem healthy until as late as a year or more. Symptoms can include ataxia, depression or stupor, unusual behaviour or disorientation, and seizures. These symptoms may worsen after a meal containing high levels of protein. Other symptoms may include anorexia (lack of appetite), vomiting/diarrhoea, pica (eating of stools and other non-food items), excessive thirst, polyuria (excessive urination), dysuria (not urinating enough), and blood in the urine. Affected puppies may have surgery, which is now proving to be more effective, although there are no long-term survivors as yet. Otherwise they die.

Research carried out into PSS in Irish wolfhounds by the Faculty of Veterinary Medicine, University of Utrecht, The Netherlands has shown that it is an inherited disease. See article in The Veterinary Record, January 7, 1995.

There has been an ongoing study into this disorder since 1996. It is being carried out by Carolyn A. Burton, BVetMed,CertVA,CertSAS,MRCVS, at the Department of Small Animal Medicine and Surgery of The Royal Veterinary College, with the breed coordinator being Jean Timmins. This study has enabled the test for the disorder to be made simpler and it is advised that all litters should be tested at six weeks. It is sensible procedure for any person wanting to buy a wolfhound puppy to make sure from the breeder that the puppies have all been tested for liver shunt.

For further information on liver shunt and the Irish wolfhound scheme, see the following Links. Excellent article entitled Recognition and Management of Portosystemic Shunts in Dogs Jean Timmins's livershunt page, with details of testing Detailed article on portosystemic shunts by Dr. Karen Tobias, Associate Professor in Small Animal Surgery at the University of Tennessee College of Veterinary Medicine Animal Disease Diagnostic Laboratory page on Portosystemic shunt American College of Veterinary Surgeons page on Portosystemic shunts

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Updated 11/14/2013